Nicole Jaff

Dr Nicole Jaff, received her PhD in 2015. Her research developed the first cohort study of menopause in black South African Women, SWEET (the study of women entering in and in endocrine transition). With 702 midlife black urban women, SWEET is the first of its kind in sub-Saharan Africa. The study characterized the natural history, clinical presentation and health effects (bone, cardiometabolic, cognitive) of menopause. This research is ongoing and her findings have been published in international medical journals, and presented internationally.

Dr Jaff is an honorary lecturer in both the Department of Chemical Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg and the Department of Clinical, Education and Health Psychology, University College, London. She is a member of the International Menopause Society (IMS), Board of Trustees, and honorary secretary on the Executive Council of the South African Menopause Society (SAMS). She represents SAMS on the Council of Affiliated Menopause Societies (CAMS), and serves on the IMS Menopause Information and Innovations committees. She is a member of the Menopause Society (formerly NAMS), a Certified Menopause Practitioner (MSCP), and a member of the Professional Board of Psychology, South Africa. She is a member of the Climacteric editorial board, and is a guest editor with Professor Nigel Crowther, of the upcoming themed Climacteric edition, ‘Menopause in LMICs’ (June 2025).

Dr Jaff co-led (with Professor Pauline Maki) the 2022 World Menopause Day initiative on Brain Fog, and has received two awards from the North American Menopause Society(NAMS) – a New Investigator award and the NAMS/Ann Voda Community Service Award, which recognizes a healthcare provider who has demonstrated outstanding community service. As joint first author, she received the 2023 SEMDSA Diabetes Award for the best original research paper. She has given numerous webinars, talks and workshops on midlife health and menopause throughout South Africa and internationally, and published four books on menopause to help midlife women improve their health and quality of life.

Education and Training

  • Ph.D.
    • School of Chemical Pathology (2015)
    • Faculty of Health Sciences
    • University of Witwatersrand, Johannesburg, South Africa
  • INTERNSHIP
    • Registered Counselor (2009)
    • FAMSA, Johannesburg
    • Dept. of Psychology, (School of Human and Community
    • Development), University of Witwatersrand, Johannesburg, South Africa
  • BA (HONS)
    • Applied Clinical Psychology (1996), First Class
    • University of the Witwatersrand, Johannesburg, South Africa

Publications - Peer Reviewed Data-Based Journal Articles

  1. Chikwati, RP, Jaff, N.G, Mahyoodeen, N.G, Micklesfield, LK, Ramsay, M. Chikwati, RP, Jaff, NG, Mahyoodeen, NG,MIckelsfield, LK, Ramsay, M, Gómez-Olivé, FX, Mohamed, SF, Choma, Solomon SSR, George, JA, Crowther NJ. 2024 The association of menopause with cardiometabolic disease risk factors in women living with and without HIV in sub-Saharan Africa: Results from the AWI-Gen 1 study. Maturitas m the AWI-Gen 1 study, (2024), https://doi.org/10.1016/j.maturitas.2024.108069
  2. Maki PM, Jaff NG. Menopause and brain fog: how to counsel and treat midlife women. Menopause. 2024 Jul 1;31(7):647-649. doi: 10.1097/GME.0000000000002382. Epub 2024 Jun 17. PMID: 38888619
  3. Mahyoodeen RP, Jaff NG, Ramsay M, Micklesfield LK, Wade AN, Agongo G, Asiki G, Choma SSR, Boua PR, George JA, Crowther NJ. 2023, Cardiometabolic disease risk factors in pre- and postmenopausal women from four sub-Saharan African countries: A cross-sectional study. Maturitas. Jun;172:60-68. doi: 10.1016/j.maturitas.2023.04.005. Epub 2023 Apr 20. PMID: 37116348; PMCID: PMC10278059.
  4. Madanhire, T., Goedecke, J.H., Ward, K.A., Jaff, N., Crowther, N.J., Norris, S., Ferrand, R.A., Rehman, A.M., Micklesfield, L.K. and Gregson, C.L. 2023, The Impact of Human Immunodeficiency Virus and Menopause on Bone Mineral Density: A Longitudinal Study of Urban-Dwelling South African Women. J Bone Miner Res.  doi.org/10.1002/jbmr.4765`
  5. Ó Breasail M, Gregson CL, Norris SA, Madanhire T, Jaff N, Crowther NJ, Micklesfield LK, Ward KA. 2022, Menopause is associated with bone loss, particularly at the distal radius, in black South African women: Findings from the Study of Women Entering and in Endocrine Transition (SWEET). Bone. 164:116543. doi: 10.1016/j.bone.2022.116543. Epub 2022 Sep 1. PMID: 36058501
  6. Maki PM, Jaff NG. Brain fog in menopause: a health-care professional's guide for decision-
    making and counseling on cognition. Climacteric. 2022, 25(6):570-578. doi: 10.1080/13697137.2022.2122792. Epub 2022 Sep 30. PMID: 36178170.
  7. Gradidge PJ, Jaff NG, Norris SA, Toman M, Crowther NJ. The negative association of lower body fat mass with cardiometabolic disease risk factors is partially mediated by adiponectin. Endocr Connect. 2022, 11(12):e220156. doi: 10.1530/EC-22-0156. PMID: 36169024; PMCID: PMC9641776.
  8. Jaff NG & Maki PM. Scientific insights into brain fog during the menopausal transition, Climacteric, 2021 24(4): 317-318, doi:  10.1080/13697137.2021.1942700
  9. Jaff NG & Crowther NJ. The association of reproductive aging with cognitive function in sub-Saharan African women. In Physical Exercise and Natural and Synthetic Products in Health and Disease, The association of reproductive aging with cognitive function in sub-Saharan African women. In Physical Exercise and Natural and Synthetic Products in Health and Disease, Methods in Molecular Biology, 2021, 2021; doiI 10.1007/978-1-0716-1558-4
  10. Jaff NG, Rubin LH, Crowther NJ, Norris SA, Maki PM. Menopausal symptoms, menopausal stage and cognitive functioning in black urban African women. Climacteric. 2020; 23(1):38- 45. doi: 10.1080/13697137.2019.1646719. Epub 2019 Aug 28.
  11. Micklesfield, LK, Kagura, J, Munthali, R, Crowther NJ, Jaff, NG, Gradidge PL, Ramsay, M, Norris SA as members of AWI-Gen theH3Africa Consortium (2018). Demographic, socio- economic and behavioural correlates of BMI in middle-aged black men and women from urban Johannesburg, South Africa. Global Health Action, 2018;1 1448250 https://doi.org/10.1080/16549716.2018.1448250
  12. Sievert L L, Jaff NG, Fugate Woods N. Stress and Midlife Women’s Health. Women’s Midlife Health 2018; 4(4) https://doi.org/10.1186/s40695-018-0034-1
  13. Jaff NG. Transdermal estradiol and micronized progesterone for preventing depression Commentary. Menopause Care Updates, the North American Menopause Society (NAMS), March 2018
  14. Micklesfield LK, Kagura J, Munthali R, Crowther NJ, Jaff NG, Gradidge P, Ramsay M and Norris SA: as members of AWI-Gen and the H3Africa Consortium (2018) Demographic, socio-economic and behavioral correlates of BMI in middle-aged black men and women from urban Johannesburg, South Africa. Glob. Health Action. 11 (sup2): 1448250. doi: 10.1080/16549716.2018.1448250
  15. Jaff NG. Depression in the Menopause Transition. Menopause Focus, 2017; 5(3):9-11
  16. Jaff NG. Calcium supplement use may increase risk of cardiovascular events in older adults: Commentary. Menopause Care Updates, the North American Menopause Society (NAMS),
    December 2016
  17. Jaff NG. Menopause in Black South Africans, adapted from a talk given by Dr. Nicole Jaff at the SAMS Congress, 27 February 2015. Menopause Focus, 2016; 4 (2): 8-11
  18. Gradidge PL, Norris SA, Jaff NG, Crowther NJ. Metabolic and Body Composition Risk Factors Associated with Metabolic Syndrome in a Cohort of Women with a High Prevalence of Cardiometabolic Disease. PLOS ONE, 2016; 11(9): e0154894 doi:10.1371/journal.pone.0162247
  19. George C, Goedecke JH, Crowther NJ, Jaff NG, Kengne AP, Norris SA, Micklesfield LK. The Role of Body Fat and Fat Distribution in Hypertension Risk in Urban Black South African Women. PLOS ONE, 2016; 11(5): e0154894. doi:10.1371/journal.pone. 154894
  20. Jaff NG, Norris SA, Snyman T, Crowther NJ. Body composition in the Study of Women Entering and in Endocrine Transition (SWEET): A perspective of African women who have a high prevalence of obesity and HIV infection. Metabolism, 2015; 64(9): 1031-1041. PMID: 26031506
  21. Jaff NG, Snyman T, Norris SA, Crowther NJ. Staging reproductive aging using Stages of Reproductive Aging Workshop + 10 in black urban African women in the Study of Women Entering and in Endocrine Transition. Menopause: The Journal of The North American Menopause Society, 2014; 21(11): 1225-1233. PMID: 24736199

Books

  1. Jaff, NG (2011) Menopause: Everything you need to know. Pan Macmillan (South Africa) Bookstorm (Pty) Ltd. Johannesburg, South Africa
  2. Jaff, NG (2009) Menopouse: Die Volledige Gids. Penguin Books (South Africa) (Pty) Ltd. Johannesburg, South Africa,
  3. Jaff, NG (2009) Menopause: A Complete Guide 2 nd Edition. Penguin Books) (Pty) Ltd. Johannesburg, South Africa
  4. Jaff, NG (2008) Menopause: A Complete Guide. Penguin Books (South Africa) (Pty) Ltd. Johannesburg, South Africa
  5. Jaff, NG (2005) Menopause Today: A Complete Guide for South African Women Penguin Books (South Africa) (Pty) Ltd. Johannesburg, South Africa,

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